Lab-in-a-Fiber detection and capture of cells

A lab-in-a-fiber component was fabricated using an optical fiber and a fiber capillary. It was used in a test suspension of fluorescently labeled and unlabeled cells and enabled detection of the labeled cells. Subsequently the labeled cells were selectively collected via suction into the capillary. A novel sampling technique reduced photobleaching of the labeled cells, extending the measurement time. The collected cells remained viable for downstream analysis. This platform's low fabrication cost, simplicity, compatibility with standard laboratory equipment, and capacity for fully automated cell capture highlights its potential for future applications in minimally invasive sample collection and point-of-care diagnostics. We demonstrate this LiF device to showcase the capability of optical fiber technology in creating low-cost, low-complexity cancer diagnostic devices. Furthermore, the LiF device holds promise for in vivo diagnostics, facilitating cell isolation and analysis.

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Publication Details

Journal
Scientific Reports
Published
2025-03-20
DOI
https://doi.org/10.1038/s41598-025-92585-6
Primary Topic
Microfluidic and Bio-sensing Technologies
Type
article
Field-Weighted Citation Impact
0.00

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article

Lab-in-a-Fiber detection and capture of cells

Rainer Heuchel, Aman Russom, Fredrik Laurell, Achar V. Harish et al.
Scientific Reports
Microfluidic and Bio-sensing Technologies
article

Lab-in-a-Fiber detection and capture of cells

Rainer Heuchel, Aman Russom, Fredrik Laurell, Achar V. Harish, Pawel Maniewski, Oana Tudoran, João Varela, Matthias Löhr, Walter Margulis, Timothy Gibbon
article en

Abstract

A lab-in-a-fiber component was fabricated using an optical fiber and a fiber capillary. It was used in a test suspension of fluorescently labeled and unlabeled cells and enabled detection of the labeled cells. Subsequently the labeled cells were selectively collected via suction into the capillary. A novel sampling technique reduced photobleaching of the labeled cells, extending the measurement time. The collected cells remained viable for downstream analysis. This platform's low fabrication cost, simplicity, compatibility with standard laboratory equipment, and capacity for fully automated cell capture highlights its potential for future applications in minimally invasive sample collection and point-of-care diagnostics. We demonstrate this LiF device to showcase the capability of optical fiber technology in creating low-cost, low-complexity cancer diagnostic devices. Furthermore, the LiF device holds promise for in vivo diagnostics, facilitating cell isolation and analysis.

Scientific ReportsVol. 15(1)
Karolinska University Hospital (SE), Pontifícia Universidade Católica do Rio de Janeiro (BR), Science for Life Laboratory (SE), RISE Research Institutes of Sweden (SE), Karolinska Institutet (SE), Institute of Oncology Prof. Dr. Ion Chiricuta (RO), KTH Royal Institute of Technology (SE)
Kungliga Tekniska Högskolan
Openalex Percentile: Top 95%
Microfluidic and Bio-sensing Technologies
DOIOpen Access PDFOpenAlex
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Lab-in-a-Fiber detection and capture of cells — Rainer Heuchel, Aman Russom, et al. · Scientific Reports (2025) | TGRS Research Map | TGRS