Asrij/OCIAD1 depletion reduces inflammatory microglial activation and ameliorates Aβ pathology in an Alzheimer’s disease mouse model
In summary, we show that Asrij depletion ameliorates Aβ pathology, neuronal and synaptic damage, gliosis, and improves behavioral performance in APP/PS1 mice. This supports that Asrij exacerbates the AD pathology. Mechanistically, Asrij is critical for the development of DAM and promotes neuroinflammatory signaling activation in microglia, thus restricting neuroprotective microglial responses. Hence, reducing Asrij in this context may help retard AD. Our work positions Asrij as a critical molecular regulator that links microglial dysfunction to AD pathogenesis.
Authors
- Maneesha S. Inamdar (ORCID: https://orcid.org/0000-0002-8243-2821)
- Thimmaiah Govindaraju (ORCID: https://orcid.org/0000-0002-9423-4275)
- Madhu Ramesh (ORCID: https://orcid.org/0000-0002-5558-7553)
- Prathamesh Dongre (ORCID: https://orcid.org/0000-0002-0791-3182)
Institutions
- Jawaharlal Nehru Centre for Advanced Scientific Research (IN)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s12974-025-03415-5
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Jawaharlal Nehru Centre for Advanced Scientific Research
- Science and Engineering Research Board