Acquired resistance to immune checkpoint therapy is caused by glycoprotein non-metastatic melanoma protein B signal cascade
Elevation of the SOX10-MITF-GPNMB signal cascade via the PDL1 receptor leads to AR. Therefore, GPNMB can be both a prognosticator of and a potential treatment target for overcoming AR to ICI treatment in RCC.
Authors
- Vinita Popat (ORCID: https://orcid.org/0000-0003-2837-842X)
- Lei Guo (ORCID: https://orcid.org/0000-0003-1733-1802)
- Jin‐Sung Chung (ORCID: https://orcid.org/0000-0001-9450-5939)
- Ponciano D. Cruz (ORCID: https://orcid.org/0000-0002-1550-6149)
- Kiyoshi Ariizumi (ORCID: https://orcid.org/0000-0002-6630-4440)
- Vijay Ramani (ORCID: https://orcid.org/0000-0002-6132-8144)
- Lin Xu (ORCID: https://orcid.org/0000-0001-5815-4457)
- Hans J. Hammers (ORCID: https://orcid.org/0000-0002-6224-4559)
Institutions
- Medpace (United States) (US)
- Veterans Health Administration (US)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1038/s43856-025-00786-x
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- U.S. Department of Defense