Enduring non-rapid eye movement sleep fragmentation following methotrexate chemotherapy in cancer-naïve mice
Methotrexate promotes NREM sleep fragmentation, without affecting sleep quality or time spent asleep. This effect is stronger in males. These data suggest that chemotherapy can cause long-term sleep disruption independent of cancer presence.
Authors
- Erin M. Gibson (ORCID: https://orcid.org/0000-0001-9749-3814)
- Adrian M. Gomez (ORCID: https://orcid.org/0000-0002-4278-8209)
- Jeremy C. Borniger (ORCID: https://orcid.org/0000-0002-5419-0271)
- Adrian Berisha
- Leah Boyd
Institutions
- Palo Alto University (US)
- Cold Spring Harbor Laboratory (US)
- Stanford University (US)
Publication Details
- Journal
- SLEEP
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1093/sleep/zsaf073
- Citations
- 3
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 4.29