What can we learn from scoliosis in children with the 22q11.2 deletion syndrome? Prognostic factors at pre-adolescent age for fast progressive, mild and self-resolving forms during adolescence
We found no evidence for the parameters in the coronal, sagittal nor transverse plane before curve onset acting as prognostic factors for curve behavior. In the prediction model on a longitudinal database that starts in many patients before scoliosis, no clear radiographic discriminant for later progressive scoliosis could be identified. The closure of the triradiate cartilage resulted as the best sign of pubertal spurt onset and scoliosis acceleration.
Authors
- Tom P. C. Schlösser (ORCID: https://orcid.org/0000-0003-1517-5914)
- René M. Castelein (ORCID: https://orcid.org/0000-0002-6182-0315)
- Sabrina Donzelli (ORCID: https://orcid.org/0000-0002-6637-7797)
- Maarten van Smeden (ORCID: https://orcid.org/0000-0002-5529-1541)
- P. Lafranca (ORCID: https://orcid.org/0000-0002-6612-1986)
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Hubrecht Institute for Developmental Biology and Stem Cell Research (NL)
- IRCCS Istituto Auxologico Italiano (IT)
Publication Details
- Journal
- Spine Deformity
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1007/s43390-025-01073-4
- Citations
- 1
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.81