Autonomic Dysfunction in Patients With Dementia With Lewy Bodies and Its Relationship With Nigrostriatal Denervation
Despite the absence of overt nOH, patients with DLB show covert dysautonomia encompassing adrenergic, parasympathetic, and sudomotor dysfunction, highlighting the importance of standardized autonomic evaluation. Patients with normal DaT-SPECT exhibited greater peripheral autonomic impairment, reflected by lower HG responses, suggesting diverse α-synuclein pathology trajectories within DLB. Further research is needed to explore autonomic nervous system dysfunctions across different DLB subtypes and stages.
Authors
- Caterina Motta (ORCID: https://orcid.org/0000-0001-6734-6979)
- Benedetta Lauretti
- Chiara Giuseppina Bonomi (ORCID: https://orcid.org/0000-0002-0881-8435)
- Alessandro Martorana (ORCID: https://orcid.org/0000-0001-8456-4169)
- Agostino Chiaravalloti (ORCID: https://orcid.org/0000-0002-8017-8858)
- Nicola Biagio Mercuri (ORCID: https://orcid.org/0000-0001-6700-7491)
- Orazio Schillaci (ORCID: https://orcid.org/0000-0002-6176-2805)
- Camilla Rocchi
- Chiara Serafini
Institutions
- University of Rome Tor Vergata (IT)
- Policlinico Tor Vergata (IT)
Publication Details
- Journal
- Neurology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1212/wnl.0000000000213463
- Citations
- 1
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.38