Uncovering drug targets for cluster headache through proteome-wide Mendelian randomization analysis
We identified a set of potential protein targets for CH, characterized by rare side effects and a strong association with the biological mechanisms underlying the disorder. These findings offer valuable insights for the development of targeted drug therapies in the treatment of CH.
Authors
- Victor J Gallardo (ORCID: https://orcid.org/0000-0002-3042-2007)
- Maiken E. Gabrielsen (ORCID: https://orcid.org/0000-0002-7132-5633)
- Elena Bacchelli (ORCID: https://orcid.org/0000-0001-8800-9568)
- Sigurður H. Magnússon (ORCID: https://orcid.org/0000-0001-6669-3071)
- Carmen Fourier (ORCID: https://orcid.org/0000-0001-6618-8948)
- Paavo Häppölä (ORCID: https://orcid.org/0000-0002-8502-0582)
- Nunu Lund (ORCID: https://orcid.org/0000-0003-3062-030X)
- Sigrid Børte (ORCID: https://orcid.org/0000-0001-9540-3256)
- Joycee Adebimpe
- Katja Heinze (ORCID: https://orcid.org/0000-0003-1483-4156)
- Daisuke Danno (ORCID: https://orcid.org/0000-0003-3737-4754)
- Felicia Jennysdotter Olofsgård (ORCID: https://orcid.org/0000-0002-1112-6130)
- Anne Heidi Skogholt (ORCID: https://orcid.org/0000-0001-7466-0405)
- Heidi Hautakangas (ORCID: https://orcid.org/0000-0002-5585-6856)
- Marta Ribasès (ORCID: https://orcid.org/0000-0003-1039-1116)
- Dwij Mehta (ORCID: https://orcid.org/0000-0002-5335-2080)
- Anna Göbel (ORCID: https://orcid.org/0000-0001-8637-9637)
- Chia‐Lin Hsu (ORCID: https://orcid.org/0000-0001-5785-0733)
- Lisanne S. Vijfhuizen (ORCID: https://orcid.org/0000-0003-1614-4589)
- Hartmut Göbel (ORCID: https://orcid.org/0000-0003-2163-112X)
- Yanliang Mei (ORCID: https://orcid.org/0000-0003-3244-6552)
- María Soler Artigas (ORCID: https://orcid.org/0000-0002-3213-1107)
- Zhonghua Xiong (ORCID: https://orcid.org/0000-0001-9488-9039)
- Olivia Quinn
- Mona Ameri Chalmer (ORCID: https://orcid.org/0000-0003-4609-1895)
- Kumar Parijat Tripathi (ORCID: https://orcid.org/0000-0002-3998-599X)
- Ting Gao (ORCID: https://orcid.org/0000-0002-6290-7885)
- Daníel F. Guðbjartsson (ORCID: https://orcid.org/0000-0002-5222-9857)
- Gyða Björnsdóttir (ORCID: https://orcid.org/0000-0002-8100-0306)
- Janice Yip (ORCID: https://orcid.org/0000-0003-4640-2729)
- Caroline Ran (ORCID: https://orcid.org/0000-0003-0239-9871)
- Espen Saxhaug Kristoffersen (ORCID: https://orcid.org/0000-0002-8999-5424)
- Ole Birger Pedersen (ORCID: https://orcid.org/0000-0003-2312-5976)
- Irene de Boer (ORCID: https://orcid.org/0000-0002-7261-762X)
- Susie Lagrata (ORCID: https://orcid.org/0000-0002-5672-5540)
- Stefanie Heilmann‐Heimbach (ORCID: https://orcid.org/0000-0003-1057-465X)
- Fahri Küçükali (ORCID: https://orcid.org/0000-0002-3835-9639)
- Sisse Rye Ostrowski (ORCID: https://orcid.org/0000-0001-5288-3851)
- Egil Ferkingstad (ORCID: https://orcid.org/0000-0001-8090-7988)
- Geyu Liu (ORCID: https://orcid.org/0009-0006-2482-1980)
- Alexander E. Volk (ORCID: https://orcid.org/0000-0001-8505-0143)
- Ida Callesen
- Yen‐Feng Wang (ORCID: https://orcid.org/0000-0001-7027-3432)
- Leopoldine A. Wilbrink (ORCID: https://orcid.org/0000-0003-1226-1059)
- Aster V. E. Harder (ORCID: https://orcid.org/0000-0002-5477-7232)
- Carolina Dalmasso (ORCID: https://orcid.org/0000-0002-4901-9955)
- Tim Kelderman (ORCID: https://orcid.org/0000-0003-4380-0721)
- Simona Guérzoni (ORCID: https://orcid.org/0000-0001-9589-2782)
- Laurent F. Thomas (ORCID: https://orcid.org/0000-0003-0548-2486)
- Anja Sofie Petersen (ORCID: https://orcid.org/0000-0002-0125-6038)
- Dong Qiu (ORCID: https://orcid.org/0000-0002-7484-2572)
- Xiaoshuang Li (ORCID: https://orcid.org/0000-0002-8615-6393)
- Amy E. Martinsen (ORCID: https://orcid.org/0000-0002-9051-9898)
- Lei Zhao (ORCID: https://orcid.org/0009-0008-4966-6424)
- Emer O’Connor
- Prasanth Sivakumar
- Axel Heinze (ORCID: https://orcid.org/0009-0001-7780-4301)
- Matti Pirinen
- Mantian Zhang (ORCID: https://orcid.org/0009-0008-0643-7605)
- Maria Michela Cainazzo
- Bendik S Winsvold
- Zhi Kai Guo
- Peng Zhang
Institutions
- Capital Medical University (CN)
- Beijing Tian Tan Hospital (CN)
- Institute of Psychology, Chinese Academy of Sciences (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s10194-025-01999-0
- Citations
- 4
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.88