Uncovering drug targets for cluster headache through proteome-wide Mendelian randomization analysis

We identified a set of potential protein targets for CH, characterized by rare side effects and a strong association with the biological mechanisms underlying the disorder. These findings offer valuable insights for the development of targeted drug therapies in the treatment of CH.

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Publication Details

Journal
The Journal of Headache and Pain
Published
2025-03-20
DOI
https://doi.org/10.1186/s10194-025-01999-0
Citations
4
Primary Topic
Migraine and Headache Studies
Type
article
Field-Weighted Citation Impact
5.88
Controls
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article

Uncovering drug targets for cluster headache through proteome-wide Mendelian randomization analysis

Victor J Gallardo, Maiken E. Gabrielsen, Elena Bacchelli, Sigurður H. Magnússon et al.
4 citations
The Journal of Headache and Pain
Migraine and Headache Studies
5.88
article

Uncovering drug targets for cluster headache through proteome-wide Mendelian randomization analysis

Victor J Gallardo, Maiken E. Gabrielsen, Elena Bacchelli, Sigurður H. Magnússon, Carmen Fourier, Paavo Häppölä, Nunu Lund, Sigrid Børte, Joycee Adebimpe, Katja Heinze, Daisuke Danno, Felicia Jennysdotter Olofsgård, Anne Heidi Skogholt, Heidi Hautakangas, Marta Ribasès, Dwij Mehta, Anna Göbel, Chia‐Lin Hsu, Lisanne S. Vijfhuizen, Hartmut Göbel, Yanliang Mei, María Soler Artigas, Zhonghua Xiong, Olivia Quinn, Mona Ameri Chalmer, Kumar Parijat Tripathi, Ting Gao, Daníel F. Guðbjartsson, Gyða Björnsdóttir, Janice Yip, Caroline Ran, Espen Saxhaug Kristoffersen, Ole Birger Pedersen, Irene de Boer, Susie Lagrata, Stefanie Heilmann‐Heimbach, Fahri Küçükali, Sisse Rye Ostrowski, Egil Ferkingstad, Geyu Liu, Alexander E. Volk, Ida Callesen, Yen‐Feng Wang, Leopoldine A. Wilbrink, Aster V. E. Harder, Carolina Dalmasso, Tim Kelderman, Simona Guérzoni, Laurent F. Thomas, Anja Sofie Petersen, Dong Qiu, Xiaoshuang Li, Amy E. Martinsen, Lei Zhao, Emer O’Connor, Prasanth Sivakumar, Axel Heinze, Matti Pirinen, Mantian Zhang, Maria Michela Cainazzo, Bendik S Winsvold, Zhi Kai Guo, Peng Zhang
article en
4 citations

Abstract

We identified a set of potential protein targets for CH, characterized by rare side effects and a strong association with the biological mechanisms underlying the disorder. These findings offer valuable insights for the development of targeted drug therapies in the treatment of CH.

The Journal of Headache and PainVol. 26(1)
Capital Medical University (CN), Beijing Tian Tan Hospital (CN), Institute of Psychology, Chinese Academy of Sciences (CN), University of Chinese Academy of Sciences (CN)
Openalex Percentile: Top 4%
Migraine and Headache Studies
5.88
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