Dual Photoredox- and Titanium Catalysis-Enabled Three-Component Radical Propargylation of Aldehydes with 1,3-Enynes
Herein, a straightforward and practical strategy involving radicals for the three-component carbonyl propargylation via dual photoredox and titanium catalysis is presented. This strategy delivers homopropargyl alcohols and includes readily available starting materials, a broad substrate scope, high functional group tolerance, and mild reaction conditions. Catalytic Cp<sub>2</sub>TiCl<sub>2</sub>, recognized as an inexpensive, nontoxic, and bench-stable titanium source, is employed.
Authors
- Lei Shi (ORCID: https://orcid.org/0000-0002-2644-1168)
- Er‐Jun Hao (ORCID: https://orcid.org/0000-0001-5821-8465)
- Zhixian Wu (ORCID: https://orcid.org/0000-0002-0708-6770)
- Xiao Feng (ORCID: https://orcid.org/0000-0002-3055-0172)
- Jing‐Ran Shan (ORCID: https://orcid.org/0009-0007-7968-7595)
- Fusheng Li (ORCID: https://orcid.org/0000-0002-5086-2130)
- Xuehan Qi
- Renxu Cao
Institutions
- University of California, Los Angeles (US)
- Dalian University of Technology (CN)
- Henan Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1021/acs.orglett.5c00719
- Citations
- 4
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Henan Province