MIF–ACKR3 Signaling Drives Cancer Cachexia by Impairing Adipogenesis

Major Finding: Macrophage migration inhibitory factor (MIF), secreted by tumor cells, hinders adipogenesis in cancer cachexia.Concept: Signaling from tumor cells to adipose stem and progenitor cells promotes adipose inflammation and fibrosis. Impact: The MIF–ACKR3 signaling axis represents a potential therapeutic target for treatment of cancer cachexia.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-031
Primary Topic
Macrophage Migration Inhibitory Factor
Type
article
Field-Weighted Citation Impact
0.00
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article

MIF–ACKR3 Signaling Drives Cancer Cachexia by Impairing Adipogenesis

Cancer Discovery
Macrophage Migration Inhibitory Factor
article

MIF–ACKR3 Signaling Drives Cancer Cachexia by Impairing Adipogenesis

article en

Abstract

Major Finding: Macrophage migration inhibitory factor (MIF), secreted by tumor cells, hinders adipogenesis in cancer cachexia.Concept: Signaling from tumor cells to adipose stem and progenitor cells promotes adipose inflammation and fibrosis. Impact: The MIF–ACKR3 signaling axis represents a potential therapeutic target for treatment of cancer cachexia.

Cancer Discovery
Openalex Percentile: Top 94%
Macrophage Migration Inhibitory Factor
DOISourceOpenAlex
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MIF–ACKR3 Signaling Drives Cancer Cachexia by Impairing Adipogenesis · Cancer Discovery (2025) | TGRS Research Map | TGRS