Gold-Catalyzed Intermolecular Assembly of Donor and Acceptor Fragments for [1,5]-Hydride Migrations
The [1,n]-hydride migration reactions represent one of the most powerful techniques to functionalize C(sp<sup>3</sup>)-H bonds and to rapidly construct molecular complexities. However, their substrates usually required multiple steps to prepare in advance. Herein, we developed a gold-catalyzed intermolecular coupling of hydride-donor-containing nucleophiles (amines) and hydride-acceptor-containing alkynes (1,3-diynamides) for cascade [1,5]-hydride migrations. Control experiments revealed the role of the dichloroethane solvent and the unexpected involvement of protonated anilines in promoting [1,5]-hydride migrations.
Authors
- Youliang Wang (ORCID: https://orcid.org/0000-0002-2613-3616)
- Yongliang Zhang (ORCID: https://orcid.org/0000-0003-3294-5503)
- Xiaoqian Zhang (ORCID: https://orcid.org/0000-0002-5873-6497)
- Ningbo Li (ORCID: https://orcid.org/0000-0002-7456-6272)
Institutions
- Peking University (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1021/acs.orglett.5c00816
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities