VacA promotes pyroptosis via TNFAIP3/TRAF1 signaling to induce onset of atrophic gastritis
The VacA/TNFAIP3/TRAF1 signaling cascade facilitates pyroptosis in H. pylori- infected tissue. Overactivation of Pyroptosis caused the atrophy-like morphological changes of gastric epithelium, further inducing sustainable malignant transformation.
Authors
- Xiaoming Liu (ORCID: https://orcid.org/0000-0002-3902-9105)
- Shilang Xiao
- Fen Wang (ORCID: https://orcid.org/0000-0002-1387-1126)
- Minglin Zhang (ORCID: https://orcid.org/0000-0002-5881-3544)
- Yi Shen (ORCID: https://orcid.org/0000-0002-2554-9812)
- Ting Cai
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- Hunan Cancer Hospital (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Microbiological Research
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1016/j.micres.2025.128142
- Citations
- 6
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.84