<scp>L</scp> -Carnitine Attenuates Cigarette Smoke-Induced Apoptosis, Cytotoxicity, and Oxidative Stress in Human Vena Cava Endothelial Cells

Background: Cigarette smoke is widely recognized as a cause of oxidative stress. There is substantial evidence indicating that it can cause changes in the structure of the endothelium, leading to an increase in reactive oxygen species (ROS). l-carnitine (LC) is a compound that facilitates the transport of fatty acids to mitochondria and contributes to energy production and cellular apoptosis. Hence, this study aimed to explore the protective properties of LC against the cytotoxic effects triggered by cigarette smoke.

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Publication Details

Journal
Applied In Vitro Toxicology
Published
2025-03-01
DOI
https://doi.org/10.1089/aivt.2024.0028
Primary Topic
Metabolism and Genetic Disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

L -Carnitine Attenuates Cigarette Smoke-Induced Apoptosis, Cytotoxicity, and Oxidative Stress in Human Vena Cava Endothelial Cells

Daniel Jahani, Mohamad Shokrzadeh, Fatemeh Shaki, Amin Reihani
Applied In Vitro Toxicology
Metabolism and Genetic Disorders
article

L -Carnitine Attenuates Cigarette Smoke-Induced Apoptosis, Cytotoxicity, and Oxidative Stress in Human Vena Cava Endothelial Cells

Daniel Jahani, Mohamad Shokrzadeh, Fatemeh Shaki, Amin Reihani
article en

Abstract

Background: Cigarette smoke is widely recognized as a cause of oxidative stress. There is substantial evidence indicating that it can cause changes in the structure of the endothelium, leading to an increase in reactive oxygen species (ROS). l-carnitine (LC) is a compound that facilitates the transport of fatty acids to mitochondria and contributes to energy production and cellular apoptosis. Hence, this study aimed to explore the protective properties of LC against the cytotoxic effects triggered by cigarette smoke.

Applied In Vitro ToxicologyVol. 11(1)
Universitat de Barcelona (ES), Mazandaran University of Medical Sciences (IR)
Zero hunger
Openalex Percentile: Top 93%
Metabolism and Genetic Disorders
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