Neonatal maternal separation causes depressive-like behavior and potentiates memory impairment induced by amyloid-β oligomers in adult mice
Neonatal MS enhances the susceptibility of adult mice to AD-associated cognitive deficits and depressive-like behavior in a sex-specific manner. This suggests that early life stress may play a role in the development of AD.
Authors
- Fernanda G. De Felice (ORCID: https://orcid.org/0000-0001-8358-0589)
- Grasielle C. Kincheski (ORCID: https://orcid.org/0000-0002-7392-3602)
- Patrick Remus Suman (ORCID: https://orcid.org/0000-0001-6468-2723)
- Sérgio T. Ferreira (ORCID: https://orcid.org/0000-0001-7160-9866)
- Rudimar Luiz Frozza (ORCID: https://orcid.org/0000-0003-0918-4128)
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- D’Or Institute for Research and Education (BR)
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Behavioral and Brain Functions
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s12993-025-00266-1
- Primary Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro