The second generation metagenomic sequencing of cerebrospinal fluid for diagnosis of non-eschar scrub typhus
Tsutsugamushi disease, is an infectious disease transmitted by ticks and caused by the rickettsiella. It is characterized by eschar, fever, rash, and flu-like symptoms. However, diagnosing atypical cases without an eschar and with negative Weil-Felix test results poses a significant diagnostic challenge. This study presents a noteworthy case of non-eschar typhus which was effectively diagnosed using advanced next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) samples.
Authors
- JiYing Zhang
- Zhangwen Ge (ORCID: https://orcid.org/0000-0001-6817-6473)
- Yi Li (ORCID: https://orcid.org/0000-0001-9315-7282)
- Shujing Li (ORCID: https://orcid.org/0009-0006-2595-3715)
- Yifei Zhu (ORCID: https://orcid.org/0000-0003-4352-6507)
- Sufang Zhang (ORCID: https://orcid.org/0000-0001-6415-0858)
- Shaoying Li (ORCID: https://orcid.org/0000-0002-6857-0523)
- Tao Zhou (ORCID: https://orcid.org/0000-0002-0878-5725)
Institutions
- Kunming Medical University (CN)
- Dali University (CN)
Publication Details
- Journal
- Oxford Medical Case Reports
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1093/omcr/omae198
- Citations
- 1
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.05