A novel PAK1/TCF1 regulatory axis promotes non-small cell lung cancer progression
This study demonstrates, for the first time, that PAK1 negatively regulates TCF1, contributing to NSCLC pathogenesis. The PAK1/TCF1 regulatory axis emerges as a critical determinant of carcinogenesis and a promising therapeutic target for NSCLC.
Authors
- Chuangang Lu
- Yinghui Xu (ORCID: https://orcid.org/0000-0002-5088-5092)
- Juan Li (ORCID: https://orcid.org/0000-0002-0992-2699)
- T. Chen
- Yingchun Su (ORCID: https://orcid.org/0000-0001-5217-9936)
- Siyuan Sheng
Institutions
- Hunan University of Arts and Science (CN)
- Sanya Central Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1007/s12672-025-02110-4
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05