Comprehensive Phenotyping and Cytokine Production of Circulating B Cells Associate Resting Memory B Cells With Early Antibody-mediated Rejection in Kidney Transplant Recipients
B-cell subset distributions differed between patients with and without rejection. Resting memory B-cell frequency was associated with increased early antibody-mediated rejection risk, whereas cytokine production and immune checkpoint expression did not influence rejection. The results suggest that B-cell subset composition could aid in rejection risk assessment and serve as a potential pretransplant diagnostic parameter.
Authors
- Carlo G. Bonasia (ORCID: https://orcid.org/0000-0002-4404-5951)
- Dania Altulea (ORCID: https://orcid.org/0000-0002-4221-5320)
- Stefan P. Berger (ORCID: https://orcid.org/0000-0003-2228-4676)
- Jan‐Stephan Sanders (ORCID: https://orcid.org/0000-0002-0904-3969)
- Peter Heeringa (ORCID: https://orcid.org/0000-0001-8684-763X)
- Theo Bijma (ORCID: https://orcid.org/0000-0002-1522-9137)
- Rosa Lammerts (ORCID: https://orcid.org/0000-0002-9970-9006)
- Nanthicha Inrueangsri (ORCID: https://orcid.org/0009-0008-1028-8403)
- Joost van den Born
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
Publication Details
- Journal
- Transplantation Direct
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1097/txd.0000000000001775
- Citations
- 2
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- Universitair Medisch Centrum Groningen