Giant ParathyroidAdenoma Causing Severe Primary Hyperparathyroidism: ACase Report

Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia in the outpatient setting, predominantly due to parathyroid adenomas. While typical adenomas are small, giant parathyroid adenomas are exceedingly rare and can mimic malignancy due to their size and biochemical profile. 1.2. Case Presentation We report a case of a 52-year-old woman presenting with chronic body aches, dizziness, and leg cramps. Laboratory investigations revealed severe hypercalcemia (14.1 mg/dL) and elevated parathyroid hormone (PTH) levels (3,654 pg/mL). Imaging via neck ultrasound and MIBI scan localized a large left inferior parathyroid adenoma. Fine needle aspiration cytology (FNAC) ruled out malignancy despite suspicious cervical lymph nodes. The patient underwent a successful left inferior parathyroidectomy, removing a 6 x 3.5 x 1.7 cm, 19.6 g adenoma. Postoperatively, PTH levels dropped significantly, and calcium levels normalized.