Safety and efficacy of long term asfotase alfa treatment in childhood hypophosphatasia
Pediatricians should consider HPP in children presenting with a suggestive clinical phenotype. Calcium-phosphorus metabolism, ALP, and vitamin B6 should always be investigated in suspected cases. Moreover, asfotase alfa represents a safe, well-tolerated, and effective drug in children with HPP.
Authors
- Cosimo Giannini (ORCID: https://orcid.org/0000-0002-2904-2744)
- Marco Castori (ORCID: https://orcid.org/0000-0002-6069-0993)
- Giulia Di Donato (ORCID: https://orcid.org/0009-0003-6066-8985)
- Saverio La Bella (ORCID: https://orcid.org/0000-0002-1244-0789)
- Luigia Cinque (ORCID: https://orcid.org/0000-0003-3157-6822)
- Armando Di Ludovico (ORCID: https://orcid.org/0000-0002-2644-1475)
- Federico Lauriola
- Luisa Silvestrini
- Luciana Breda (ORCID: https://orcid.org/0000-0002-1088-524X)
- Francesco Chiarelli
- Debora Mariarita d’Angelo
Institutions
- Casa Sollievo della Sofferenza (IT)
- University of Chieti-Pescara (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- The Italian Journal of Pediatrics/Italian journal of pediatrics
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s13052-025-01883-2
- Citations
- 1
- Primary Topic
- Alkaline Phosphatase Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.29