The Value of Detecting Creatinine and Human Chorionic Gonadotropin (Hcg) Levels in Cervicovaginal Discharge in Identifying Leakage in Pregnant Women 24 to 37 Weeks with Clear Leakage or Positive Fern Test

Background: Premature birth is one of the most important midwifery problems, and its early diagnosis is essential in the treatment and prevention process. Therefore, the purpose of this study is the value of detecting the level of creatinine and human chorionic gonadotropin (HCG) in cervicovaginal secretions in detecting discharge in pregnant women of 24 to 37 weeks with clear discharge or a positive Fern test in Forghani Hospital in 2022. Materials and methods: This study was conducted on 230 pregnant women from 24 to 37 weeks suspected of having vaginal discharge. In all suspected women, the creatinine and HCG levels of cervicovaginal secretions were measured, and the results were analyzed based on clear discharge and Fern's test, then the diagnostic power was calculated based on Rock's curve. Results: Our study's findings showed that the average levels of creatinine and B-HCG in women with clear discharge or a positive Fern test were significantly higher than in other women. However, by examining the diagnostic accuracy, it was found that the degree of agreement between the two tests in diagnosing discharge Clear and positive Fern test is weak to moderate, and creatinine has high sensitivity and B-HCG has high specificity. Conclusion: Creatinine and BHCG can be used in the diagnosis of premature rupture along with standard tests, and due to the use of a valuable diagnostic method, the fatal complications of PROM can be prevented, and with the timely treatment of this complication, the dangerous consequences are reduced, a study with higher sample volume and careful control of confounders is required.