Higher level of HBsAg associated with delayed development of HCC in immune-tolerant patients
Predictive roles of HBV DNA and HBsAg levels in HCC development differ between HBeAg-negative and HBeAg-positive patients. Particularly, among immune-tolerant patients, HBsAg levels ≥10,000 IU/mL showed delayed development of HCC, suggesting HBsAg as a biomarker to define genuine immune-tolerant patients.
Authors
- Hung‐Chih Yang (ORCID: https://orcid.org/0000-0003-3864-9895)
- Tung‐Hung Su (ORCID: https://orcid.org/0000-0002-6747-7941)
- Tetsuya Hosaka (ORCID: https://orcid.org/0000-0003-0302-2275)
- Hwai‐I Yang (ORCID: https://orcid.org/0000-0002-3433-942X)
- Chen‐Hua Liu (ORCID: https://orcid.org/0000-0003-3622-9707)
- Pei‐Jer Chen (ORCID: https://orcid.org/0000-0001-8316-3785)
- Jia‐Horng Kao (ORCID: https://orcid.org/0000-0002-2442-7952)
- Mei‐Hung Pan (ORCID: https://orcid.org/0000-0002-0121-8242)
- Chun‐Jen Liu (ORCID: https://orcid.org/0000-0002-6202-0993)
- Wanting Yang (ORCID: https://orcid.org/0000-0002-6918-3701)
- Fumitaka Suzuki (ORCID: https://orcid.org/0000-0001-5232-796X)
- Tai‐Chung Tseng (ORCID: https://orcid.org/0000-0003-0420-8311)
- Chien-Jen Chen
- Hiromitsu Kumada
Institutions
- National Sun Yat-sen University (TW)
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- National Taiwan University (TW)
- Genomics Research Center, Academia Sinica (TW)
- National Taiwan University Hospital (TW)
- Toranomon Hospital (JP)
- Academia Sinica (TW)
Publication Details
- Journal
- Hepatology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1097/hep.0000000000001313
- Citations
- 7
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 9.48