Mediation Analyses Link Cardiometabolic Factors and Liver Fat With White Matter Hyperintensities and Cognitive Performance: A UK Biobank Study
Our findings indicate that liver fat mediates associations between cardiometabolic factors and WMHs and that WMHs mediate the association between liver fat and cognitive performance. This suggests that liver fat may be important for understanding the effects of cardiometabolic factors on cerebrovascular disease and cognitive function. Experimental studies are warranted to determine relevant targets for preventing vascular-driven cognitive impairment.
Authors
- Lars Tjelta Westlye (ORCID: https://orcid.org/0000-0001-8644-956X)
- Olav B. Smeland (ORCID: https://orcid.org/0000-0002-3761-5215)
- Ole A. Andreassen (ORCID: https://orcid.org/0000-0002-4461-3568)
- Max Korbmacher (ORCID: https://orcid.org/0000-0002-8113-2560)
- Tiril P. Gurholt (ORCID: https://orcid.org/0000-0002-1272-7616)
- Sigrun Halvorsen (ORCID: https://orcid.org/0000-0001-7561-7644)
- Ann‐Marie G. de Lange (ORCID: https://orcid.org/0000-0002-5150-6656)
- Daniel E. Askeland-Gjerde (ORCID: https://orcid.org/0009-0001-7266-2981)
- Dennis van der Meer (ORCID: https://orcid.org/0000-0002-9473-4536)
- Patrik Andersson (ORCID: https://orcid.org/0000-0001-9807-446X)
Institutions
- Oslo University Hospital (NO)
- Western Norway University of Applied Sciences (NO)
- University of Oslo (NO)
- Haukeland University Hospital (NO)
- Maastricht University (NL)
- University of Oxford (GB)
- University of Lausanne (CH)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100488
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06