Lack of pre-movement facilitation as neurophysiological hallmark of fatigue in patients with Parkinson's disease: A single pulse TMS study
These findings suggest that cortical dysfunction in motor preparation contributes to PD-related fatigue, particularly in the most affected hemisphere. The observed PMF deficits provide a potential neurophysiological marker for fatigue in PD, supporting future investigations into targeted therapeutic interventions to restore motor excitability and alleviate fatigue symptoms.
Authors
- Giovanni Cirillo (ORCID: https://orcid.org/0000-0003-3183-8773)
- Carla Cavaliere (ORCID: https://orcid.org/0000-0002-2048-7819)
- Andrea Soricelli (ORCID: https://orcid.org/0000-0001-7011-7667)
- Ciro De Luca
- Giuseppe Rocco (ORCID: https://orcid.org/0000-0002-8043-1083)
- Giovanna Vermiglio
- Marco Aiello (ORCID: https://orcid.org/0000-0002-3676-0664)
- Giovanna Sepe
- Antimo Buonocore (ORCID: https://orcid.org/0000-0003-3917-510X)
- Michèle Papa (ORCID: https://orcid.org/0000-0002-6609-7453)
- Celeste Cafaro
Institutions
- University of Messina (IT)
- Università degli Studi Suor Orsola Benincasa (IT)
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1016/j.nbd.2025.106878
- Citations
- 1
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.84