Copper-Catalyzed Regioselective Dihydroboration of Alkynes to Construct <i>gem</i>-Diborylalkanes
We develop herein an efficient copper-catalyzed dihydroboration of alkynes with HBpin to synthesize <i>gem</i>-diborylalkanes. This catalytic process features a broad substrate scope, good functional group tolerance, and excellent regioselectivity. Notably, the gram-scale reaction and further product derivatizations demonstrate the practicality of this protocol. Preliminary mechanistic studies indicate that the process involves the hydroboration of the alkyne and the vinylboronate intermediate.
Authors
- Wanxiang Zhao (ORCID: https://orcid.org/0000-0002-6313-399X)
- Zheming Liu
- Wenke Dong (ORCID: https://orcid.org/0009-0005-0012-4905)
- Guanglu Liu
- Zhenyuan Zhang (ORCID: https://orcid.org/0000-0003-3356-0111)
- Minghao Zhang (ORCID: https://orcid.org/0000-0003-3337-890X)
- Y.-B. Wei
Institutions
- Hunan University (CN)
- Zhoukou Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1021/acs.orglett.5c00943
- Citations
- 6
- Primary Topic
- Organoboron and organosilicon chemistry
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- Zhoukou Normal University
- National Natural Science Foundation of China
- Science and Technology Program of Hunan Province