Immune profiling of gastric adenocarcinomas in EU and LATAM countries identifies global differences in immune subgroups and microbiome influence

Both EU and LATAM countries have GCs with a T cell inflamed microenvironment that might benefit from checkpoint inhibition. We identified a highly inflamed GC subgroup that lacked antigen presentation and cytotoxicity associated with H. pylori CagA-positive strains, suggesting their contribution to tumor immune tolerance. Future studies are needed to unravel whether these cancers benefit from immunotherapy as well.

Authors

Institutions

Publication Details

Journal
British Journal of Cancer
Published
2025-03-20
DOI
https://doi.org/10.1038/s41416-025-02979-6
Primary Topic
Helicobacter pylori-related gastroenterology studies
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Immune profiling of gastric adenocarcinomas in EU and LATAM countries identifies global differences in immune subgroups and microbiome influence

Carmelo Caballero, Angélica Hernández-Guerrero, Marc Díez, Manuel Cabeza-Segura et al.
British Journal of Cancer
Helicobacter pylori-related gastroenterology studies
article

Immune profiling of gastric adenocarcinomas in EU and LATAM countries identifies global differences in immune subgroups and microbiome influence

Carmelo Caballero, Angélica Hernández-Guerrero, Marc Díez, Manuel Cabeza-Segura, Erika Ruíz‐García, Berenice Freile, Rita Barros, Cinthia Gauna, Juan Antonio Carbonell‐Asins, Gareth I. Owen, Sarah Derks, María Alsina, Fátima Carneiro, Roos E. Pouw, Elena Jiménez-Martí, Edith A. Fernández-Figueroa, Hugo Boggino, Andreia Costa, Rui M. Ferreira, Florian Lordick, Tania Fleitas, Juan Carlos Roa, Federico Esteso, Céu Figueiredo, Leonardo Saul Lino-Silva, Rosana Villagrasa, Marcelo Garrido, Erick Riquelme, Judith Farrés, Juan O ́Connor, João Santos‐Antunes, Fiorella Ruíz‐Pace, Daniel Cantero, Rodrigo Dienstmann, Arnoldo J. Riquelme, Ana Miralles-Marco, Carolina Martínez‐Ciarpaglini, Andrés Cervantes, Tessa S. Groen-van Schooten, Rita Pereira, Gonzalo Latorre
article en

Abstract

Both EU and LATAM countries have GCs with a T cell inflamed microenvironment that might benefit from checkpoint inhibition. We identified a highly inflamed GC subgroup that lacked antigen presentation and cytotoxicity associated with H. pylori CagA-positive strains, suggesting their contribution to tumor immune tolerance. Future studies are needed to unravel whether these cancers benefit from immunotherapy as well.

British Journal of CancerVol. 132(9)
Universidad Mayor (CL), Universitat de València (ES), Pontificia Universidad Católica de Chile (CL), Universidade do Porto (PT), Dutch Cancer Society (NL), Instituto de Salud Carlos III (ES), Hospital Clínico Universitario de Valencia (ES), Administração Regional de Saúde de Lisboa e Vale do Tejo (PT), National Institute of Genomic Medicine (MX), Oncode Institute (NL), Navarrabiomed (ES), Guyra Paraguay (PY), Instituto Alexander Fleming (AR), Vall d'Hebron Hospital Universitari (ES), Amsterdam University Medical Centers (NL), Instituto Nacional de Cancerología (MX), INCLIVA Health Research Institute (ES), i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT), Millennium Institute on Immunology and Immunotherapy (CL), Anaxomics (Spain) (ES), IPS Central (PY), Cancer Center Amsterdam (NL), Vall d'Hebron Institute of Oncology (ES), Vrije Universiteit Amsterdam (NL), Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Institut Català de Nanociència i Nanotecnologia, European Commission, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Agencia Nacional de Investigación y Desarrollo, Oncode Institute, Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias
Partnerships for the goals
Openalex Percentile: Top 91%
Helicobacter pylori-related gastroenterology studies
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.