Immune profiling of gastric adenocarcinomas in EU and LATAM countries identifies global differences in immune subgroups and microbiome influence
Both EU and LATAM countries have GCs with a T cell inflamed microenvironment that might benefit from checkpoint inhibition. We identified a highly inflamed GC subgroup that lacked antigen presentation and cytotoxicity associated with H. pylori CagA-positive strains, suggesting their contribution to tumor immune tolerance. Future studies are needed to unravel whether these cancers benefit from immunotherapy as well.
Authors
- Carmelo Caballero
- Angélica Hernández-Guerrero (ORCID: https://orcid.org/0000-0002-6957-3531)
- Marc Díez (ORCID: https://orcid.org/0000-0002-9473-0391)
- Manuel Cabeza-Segura (ORCID: https://orcid.org/0000-0002-3257-1292)
- Erika Ruíz‐García (ORCID: https://orcid.org/0000-0002-0446-123X)
- Berenice Freile (ORCID: https://orcid.org/0000-0003-3192-126X)
- Rita Barros (ORCID: https://orcid.org/0000-0002-1667-7329)
- Cinthia Gauna (ORCID: https://orcid.org/0009-0001-5669-8431)
- Juan Antonio Carbonell‐Asins (ORCID: https://orcid.org/0000-0002-8449-5674)
- Gareth I. Owen (ORCID: https://orcid.org/0000-0003-3807-6054)
- Sarah Derks (ORCID: https://orcid.org/0000-0002-4547-7457)
- María Alsina (ORCID: https://orcid.org/0000-0003-4835-7159)
- Fátima Carneiro (ORCID: https://orcid.org/0000-0002-1964-1006)
- Roos E. Pouw (ORCID: https://orcid.org/0000-0002-4707-1186)
- Elena Jiménez-Martí (ORCID: https://orcid.org/0000-0002-1537-5337)
- Edith A. Fernández-Figueroa (ORCID: https://orcid.org/0000-0002-5159-8300)
- Hugo Boggino (ORCID: https://orcid.org/0009-0002-7615-7023)
- Andreia Costa (ORCID: https://orcid.org/0000-0002-5331-9934)
- Rui M. Ferreira (ORCID: https://orcid.org/0000-0003-0961-2356)
- Florian Lordick (ORCID: https://orcid.org/0000-0001-8591-9339)
- Tania Fleitas (ORCID: https://orcid.org/0000-0002-2789-9082)
- Juan Carlos Roa (ORCID: https://orcid.org/0000-0001-8313-8774)
- Federico Esteso (ORCID: https://orcid.org/0000-0003-1977-9846)
- Céu Figueiredo (ORCID: https://orcid.org/0000-0001-5247-840X)
- Leonardo Saul Lino-Silva (ORCID: https://orcid.org/0000-0002-7394-5123)
- Rosana Villagrasa
- Marcelo Garrido (ORCID: https://orcid.org/0000-0001-8905-8986)
- Erick Riquelme (ORCID: https://orcid.org/0000-0002-2696-7995)
- Judith Farrés (ORCID: https://orcid.org/0000-0002-0958-0510)
- Juan O ́Connor
- João Santos‐Antunes (ORCID: https://orcid.org/0000-0003-0614-0576)
- Fiorella Ruíz‐Pace (ORCID: https://orcid.org/0000-0002-3932-0170)
- Daniel Cantero
- Rodrigo Dienstmann (ORCID: https://orcid.org/0000-0001-5997-318X)
- Arnoldo J. Riquelme (ORCID: https://orcid.org/0000-0002-8259-8960)
- Ana Miralles-Marco (ORCID: https://orcid.org/0000-0001-9720-0348)
- Carolina Martínez‐Ciarpaglini (ORCID: https://orcid.org/0000-0002-8797-2114)
- Andrés Cervantes (ORCID: https://orcid.org/0000-0003-3806-3691)
- Tessa S. Groen-van Schooten (ORCID: https://orcid.org/0009-0004-7749-929X)
- Rita Pereira (ORCID: https://orcid.org/0000-0001-6127-8637)
- Gonzalo Latorre (ORCID: https://orcid.org/0009-0000-2311-8747)
Institutions
- Universidad Mayor (CL)
- Universitat de València (ES)
- Pontificia Universidad Católica de Chile (CL)
- Universidade do Porto (PT)
- Dutch Cancer Society (NL)
- Instituto de Salud Carlos III (ES)
- Hospital Clínico Universitario de Valencia (ES)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- National Institute of Genomic Medicine (MX)
- Oncode Institute (NL)
- Navarrabiomed (ES)
- Guyra Paraguay (PY)
- Instituto Alexander Fleming (AR)
- Vall d'Hebron Hospital Universitari (ES)
- Amsterdam University Medical Centers (NL)
- Instituto Nacional de Cancerología (MX)
- INCLIVA Health Research Institute (ES)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- Millennium Institute on Immunology and Immunotherapy (CL)
- Anaxomics (Spain) (ES)
- IPS Central (PY)
- Cancer Center Amsterdam (NL)
- Vall d'Hebron Institute of Oncology (ES)
- Vrije Universiteit Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1038/s41416-025-02979-6
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut Català de Nanociència i Nanotecnologia
- European Commission
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Agencia Nacional de Investigación y Desarrollo
- Oncode Institute
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias