Evaluation of biochemical markers in relation to psychological well-being in adolescents with polycystic ovary syndrome

Objective: This study examines psychological well-being levels among adolescents with polycystic ovary syndrome (PCOS) by levels of biochemical markers used for their diagnoses. Methods: A cross-sectional study involved 45 adolescent females with PCOS at a pediatric endocrinology outpatient clinic. Data, including demographics, clinical exams, and lab results, were recorded at enrollment. Initial blood samples included metabolic and hormonal markers. Mental health was assessed using the Depression Anxiety Stress Scale (DASS)-42 questionnaire. Results: The study provides valuable insights into the possible metabolic and hormonal influences on mental health in adolescents with PCOS, detecting that total testosterone (TT) exhibits high sensitivity for depression, while aspartate transaminase (AST) presents notable specificity for stress. Anxiety did not show a significant link with laboratory data. Conclusion: TT exhibits high sensitivity for depression, while AST presents notable specificity for stress. Both markers suggest diagnostic potential in their respective categories, necessitating further research for validation.