Diabetes mellitus and <i>APOL1</i> genotype increase the risk for chronic kidney disease progression in sickle cell disease
We observed diabetes mellitus (DM) in 9.3% of adults with sickle cell disease (SCD), and DM predicted a sevenfold greater risk of chronic kidney disease progression adjusting for high-risk APOL1. Our results emphasize the clinical significance of DM in SCD.
Authors
- Franklin Njoku (ORCID: https://orcid.org/0000-0003-4171-3202)
- Anand Srivastava (ORCID: https://orcid.org/0000-0002-8109-1420)
- Victor R. Gordeuk (ORCID: https://orcid.org/0000-0003-4725-7295)
- Brian Thomas Layden (ORCID: https://orcid.org/0000-0003-2176-5654)
- Insia Rizvi (ORCID: https://orcid.org/0009-0006-7092-5860)
- Santosh L. Saraf (ORCID: https://orcid.org/0000-0002-8584-4194)
- Robert E. Molokie (ORCID: https://orcid.org/0000-0003-3623-7395)
- Jin Han (ORCID: https://orcid.org/0000-0003-0662-006X)
- Marwah Farooqui (ORCID: https://orcid.org/0000-0001-8394-8419)
- Ryan Sun
- Joseph L. Zapater (ORCID: https://orcid.org/0000-0002-1116-7776)
- Zalaya Ivy (ORCID: https://orcid.org/0000-0002-3185-1786)
Institutions
- University of Illinois Chicago (US)
- University of Chicago (US)
- Jesse Brown VA Medical Center (US)
Publication Details
- Journal
- Blood
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1182/blood.2024027839
- Citations
- 1
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.63