Gene deletion as a possible strategy adopted by New World Leishmania infantum to maximize geographic dispersion
Phenotypic assessments reveal altered parasite fitness, with potential enhanced transmissibility at the population level. Reduced susceptibility of DEL strains to miltefosine, a key drug in VL treatment, further complicates control efforts. The study underscores the importance of typing parasite genomes for surveillance and control, advocating for the sub-chromosomal deletion as a molecular marker in AVL management.
Authors
- Jullyanna Oliveira
- Flávia Lima Ribeiro-Gomes (ORCID: https://orcid.org/0000-0003-0297-6341)
- Ingrid Waclawiak (ORCID: https://orcid.org/0000-0002-3018-132X)
- Erich Loza Telleria (ORCID: https://orcid.org/0000-0003-0006-0057)
- Yara Maria Traub-Csekö (ORCID: https://orcid.org/0000-0002-9676-3381)
- Slavica Vaselek (ORCID: https://orcid.org/0000-0002-9105-7138)
- Petr Volf (ORCID: https://orcid.org/0000-0003-1790-1123)
- Thamara Kelcya Fonseca Oliveira (ORCID: https://orcid.org/0009-0000-6392-7127)
- Otacílio C. Moreira (ORCID: https://orcid.org/0000-0002-5340-8697)
- Tereza Leštinová (ORCID: https://orcid.org/0000-0001-5518-2268)
- Mariana Côrtes Boité (ORCID: https://orcid.org/0000-0002-2903-6280)
- José Roberto Meyer‐Fernandes (ORCID: https://orcid.org/0000-0003-2728-3138)
- Anderson B. Guimarães-Costa (ORCID: https://orcid.org/0000-0003-4582-1980)
- Anita Leocádio Freitas-Mesquita
- Elvira M. Saraiva (ORCID: https://orcid.org/0000-0002-6388-5286)
- Elisa Cupolillo (ORCID: https://orcid.org/0000-0002-0620-3250)
- Monique Florêncio
- Laura Aragão-Farias (ORCID: https://orcid.org/0009-0000-1676-4812)
- Camilly Enes Trindade
- Marne Coimbra Batalha Chagas
- Patricia Cuervo Escobar
- Gerald Frank Späth (ORCID: https://orcid.org/0000-0002-0256-2029)
- Renata Azevedo do Nascimento
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Inserm (FR)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Charles University (CZ)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- PLoS Pathogens
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1371/journal.ppat.1012938
- Citations
- 4
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Ministerstvo Vnitra České Republiky
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Institut Pasteur
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Fundação Oswaldo Cruz
- Philippine-American Educational Foundation