DNA methylation heterogeneity correlates with field cancerization and prognosis in lung adenocarcinoma patients
Our findings revealed distinct methylation patterns between tumor and pre-malignant samples, such as peri-tumor and normal tissues. Moreover, our study suggests that distinct clustering based on DNA methylation may indicate different prognoses in LUAD patients.
Authors
- Tengfei Zhu
- Yang He (ORCID: https://orcid.org/0000-0002-7460-5649)
- Bing Keong Li (ORCID: https://orcid.org/0000-0001-6983-7253)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-4530-6754)
- Yun Wang (ORCID: https://orcid.org/0009-0009-6064-0871)
- Ying Zhou (ORCID: https://orcid.org/0000-0003-3607-8216)
- Yanjun Su (ORCID: https://orcid.org/0009-0002-0725-1243)
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Burning Rock Biotech (China) (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s13148-025-01845-9
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61