Early recovery of leukocyte subsets is associated with favorable progression-free survival in patients with inoperable stage II/III NSCLC after multimodal treatment: a prospective explorative study
Our results suggest that two parameters commonly assessed in clinical routine can be used to predict patient outcome. These are: early increase in CD8 + T-cell lymphocyte count and variability in IL-6 plasma concentration, that are correlated to patients with favorable, respectively, poor outcome after definitive therapy independent of treatment regimen.
Authors
- Lukas Käsmann (ORCID: https://orcid.org/0000-0001-6260-5249)
- Chukwuka Eze (ORCID: https://orcid.org/0000-0003-3779-1398)
- Alexander Nieto (ORCID: https://orcid.org/0000-0002-6454-8337)
- Claus Belka (ORCID: https://orcid.org/0000-0002-1287-7825)
- Julian Taugner (ORCID: https://orcid.org/0000-0003-1473-1202)
- Farkhad Manapov
- Elfriede Noeßner (ORCID: https://orcid.org/0000-0003-4709-9266)
- Thomas P. Hofer (ORCID: https://orcid.org/0000-0002-9713-3138)
- Saloni Mathur
- Carolyn Pelikan
Institutions
- Helmholtz Zentrum München (DE)
- LMU Klinikum (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s13014-025-02620-z
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00