Benzamide‐Directed Hydroarylative Cross‐Couplings Using Minimally Activated Alkenes: Enantioselective Synthesis of Tertiary and Quaternary Stereocenters
Ir-systems modified with ferrocene-based homochiral diphosphonite ligands, prepared from functionalized SPINOL derivatives, promote benzamide-directed hydroarylative cross-couplings involving minimally activated alkenes. The processes are highly branched selective and enantioselective. Accordingly, tertiary benzylic stereocenters are generated under byproduct-free conditions. This contrast with conventional cross-coupling approaches, which are less step and atom economical. Preliminary results show that the process extends to the formation of quaternary benzylic stereocenters.
Authors
- Timothy P. Aldhous (ORCID: https://orcid.org/0000-0003-2031-7454)
- Lyman J. Feron
- Raymond T. Chung (ORCID: https://orcid.org/0000-0003-1338-9564)
- Paul D. Kemmitt (ORCID: https://orcid.org/0000-0002-5374-6557)
- John F. Bower (ORCID: https://orcid.org/0000-0002-7551-8221)
- Simon Grélaud
- Andrew G. Dalling (ORCID: https://orcid.org/0000-0001-9336-8717)
- Richard J. Mudd (ORCID: https://orcid.org/0000-0002-4988-7496)
- Phillippa Cooper (ORCID: https://orcid.org/0000-0002-8422-0945)
- Abbas Hassan (ORCID: https://orcid.org/0000-0001-6088-431X)
Institutions
- AstraZeneca (United Kingdom) (GB)
- University of Liverpool (GB)
- Al Ain University (AE)
- United Arab Emirates University (AE)
- University of Bristol (GB)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1002/anie.202502569
- Citations
- 6
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 3.22