Comparison of chromosome analysis, factor V Leiden, and prothrombin G20210A mutation results according to the number of pregnancy losses in recurrent pregnancy loss

Objective: Recurrent pregnancy loss is defined as the loss of two or more pregnancies in some sources, or three or more in others, before 20-24 weeks of gestation. The causes being investigated include parental chromosomal abnormalities and hereditary thrombophilia. We aimed to reveal the frequency of parental chromosome abnormalities, Prothrombin G20210A mutations (PGM), and Factor V Leiden (FVL) in couples presenting with recurrent pregnancy losses and to test whether there is a significant difference between two and more than two pregnancy losses. Materials and Methods: A total of 171 couples who presented to the Medical Genetics outpatient clinics of two tertiary hospitals located in Bolu and Hatay provinces due to a history of recurrent pregnancy loss were evaluated. Demographic data, medical and family history, chromosomal analysis results of the couples, and FVL and PGM results of the women were recorded. Results: We detected chromosomal abnormalities in 2.9% of those evaluated. Factor V Leiden frequency was found to be 11.5% and PGM frequency was 3%. No statistically significant distinction was obtained between the groups, categorized as those with two and more than two pregnancy losses, in terms of the occurrence of chromosomal abnormalities (p=0.65), FVL (p=0.58), and PGM (p=0.65). Conclusion: A similar approach to requesting a test can be taken for both patient groups. Due to the limited number of patients, a meta-analysis of this result with other case series in Turkey would be beneficial.