Pathological complete response, histologic grade, and level of stromal tumor-infiltrating lymphocytes in ER + HER2- breast cancer
High tumor grade and sTIL levels were associated with higher rates of pCR in ER + HER2- breast cancer. Our findings support that the addition to ICIs to NAC increased pCR in high-risk, HG III, ER + HER2- breast cancer and suggest that sTIL levels could be utilized to identify patients with ER + HER2- breast cancer eligible for chemoimmunotherapy.
Authors
- Seung Ho Baek (ORCID: https://orcid.org/0000-0001-8062-470X)
- Sung Gwe Ahn (ORCID: https://orcid.org/0000-0002-8778-9686)
- Yoonwon Kook (ORCID: https://orcid.org/0000-0002-0756-738X)
- Joon Jeong (ORCID: https://orcid.org/0000-0003-0397-0005)
- Yoon Jin (ORCID: https://orcid.org/0000-0002-5967-4064)
- Soong June Bae (ORCID: https://orcid.org/0000-0002-0012-9694)
- Min Ji Lee
Institutions
- Yonsei University (KR)
- Severance Hospital (KR)
- Gangnam Severance Hospital (KR)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s13058-025-01999-7
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Research Foundation
- Yonsei University
- National Research Foundation of Korea
- Yonsei University College of Medicine