Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner
Overall, our study may suggest that targeting αSyn and its role in modulating the DDR and melanomagenesis could serve as a promising new therapeutic target.
Authors
- Moriah R. Arnold (ORCID: https://orcid.org/0000-0002-5916-7978)
- Suzie Chen (ORCID: https://orcid.org/0000-0002-6384-5081)
- Vivek K. Unni (ORCID: https://orcid.org/0000-0001-8833-6542)
Institutions
- Rutgers, The State University of New Jersey (US)
- Oregon Health & Science University (US)
- Center for Neurosciences (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fonc.2025.1554059
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Melanoma Research Foundation
- Melanoma Research Alliance
- Kuni Foundation
- National Institute for Health and Care Research
- National Institute on Aging