Neoadjuvant chemotherapy response in androgen receptor-positive triple-negative breast cancer: potential predictive biomarkers and genetic alterations
The current study indicated that the AR-positive TNBC is correlated with lower rates of pCR after NACT. The expression of FOXC1 in TNBC patients and AR-positive TNBC patients could be utilized as a predictive marker for the efficacy of NACT. The present study provides a rationale for treating these non-pCR AR-positive TNBC tumors with PI3K/AKT/mTOR inhibitors.
Authors
- Ming D. Li (ORCID: https://orcid.org/0000-0002-6873-9472)
- Wentao Yang (ORCID: https://orcid.org/0000-0001-7712-822X)
- Shuling Zhou (ORCID: https://orcid.org/0000-0001-5984-7415)
- Mengyuan Cai (ORCID: https://orcid.org/0000-0002-1152-5895)
- Hong Lv
- Ruohong Shui
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s13058-025-01994-y
- Citations
- 3
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China