Efficacy and safety of polymyxin B sulfate versus colistin sulfate in ICU patients with nosocomial pneumonia caused by carbapenem-resistant Acinetobacter baumannii: a multicenter, propensity score-matched, real-world cohort study

This study establishes that PMB and CS have similar efficacy in treating CRAB induced nosocomial pneumonia in the ICU settings. The incidence of AKI and hepatotoxicity of both polymyxins are comparable for both polymyxins, although PMB is associated with a significantly higher incidence of skin toxicity. Ensuring adequate therapy duration is key to better outcomes in the treatment of CRAB-induced nosocomial pneumonia in ICU patients, regardless of the type of polymyxins.