A new hybrid post-translational modification—have you lost your (MARUb)les?
Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) moiety. This “MARUbylation” is likely to play important functions during interferon signalling, a core component of innate immunity.
Authors
- Isaac de Araújo Matos (ORCID: https://orcid.org/0000-0002-8089-8871)
- Nícolas C. Hoch (ORCID: https://orcid.org/0000-0002-7610-1305)
Institutions
- Universidade de São Paulo (BR)
Publication Details
- Journal
- The EMBO Journal
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1038/s44318-025-00413-4
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo