Stable dispersion and prolonged dissolution of hydrophilic pharmaceutical achieved by room-temperature atmospheric pressure atomic layer deposition
We demonstrate atomic layer deposition of SiO<sub>2</sub> films on hydrophilic diclofenac sodium pharmaceutical powder under ambient conditions. We reveal that the SiO<sub>2</sub> layer not only prolongs the dissolution but also enhances the surface zeta potential of the coated products, preventing sedimentation and enabling a highly stable dispersion in water.
Authors
- Tuan Hiep Tran (ORCID: https://orcid.org/0000-0002-8732-8230)
- Viet Cao (ORCID: https://orcid.org/0000-0003-2219-0776)
- Kim-Hue Thi Dinh
- Hao Van Bui (ORCID: https://orcid.org/0000-0003-2256-7270)
- Phi Huu Bui
- Tuan Thanh Dinh
Institutions
- Phenikaa University (VN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4cc06707j
- Citations
- 1
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.52