Insights from DCE-MRI: blood–brain barrier permeability in the context of MS relapses and methylprednisolone treatment
These results support the use of K<sub>i</sub> alongside conventional MRI imaging metrics, to improve clinical relapse prediction in RRMS. The findings underscore the utility of K<sub>i</sub> as a marker of MS-related neuroinflammation, with potential for integration into relapse monitoring protocols. Further validation in larger cohorts is recommended to confirm the model's generalizability and clinical application.
Authors
- Henrik Larsson (ORCID: https://orcid.org/0000-0002-1348-7749)
- Ulrich Lindberg (ORCID: https://orcid.org/0000-0002-0004-6354)
- Nizar Hamrouni
- Ian Galea (ORCID: https://orcid.org/0000-0002-1268-5102)
- Aravinthan Varatharaj (ORCID: https://orcid.org/0000-0003-1629-5774)
- Stig P. Cramer (ORCID: https://orcid.org/0000-0003-2959-2161)
- Jette Lautrup Frederiksen (ORCID: https://orcid.org/0000-0003-1661-7438)
- Helle Juhl Simonsen
- Mark B. Vestergaard
Institutions
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- University Hospital Southampton NHS Foundation Trust (GB)
- University of Southampton (GB)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fnins.2025.1546236
- Citations
- 2
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Scleroseforeningen
- Multiple Sclerosis Society
- Rigshospitalet