Ocular ischaemic syndrome due to giant cell arteritis

Giant cell arteritis (GCA) is a large vessel vasculitis with devastating visual consequences if left untreated. Classically, GCA has a predilection for the short posterior ciliary arteries which supply the optic nerve head, causing sudden painless visual loss with the development of arteritic anterior ischaemic optic neuropathy (AAION). Other ocular manifestations of GCA include central retinal artery occlusion, oculomotor nerve palsy, posterior ischaemic optic neuropathy and ocular ischaemic syndrome (OIS). OIS is a rare clinical entity, typically stemming from severe, unilateral carotid artery disease. It may present with anterior segment ischaemia heralded by hypotony and corneal oedema. Rarely, it may occur in cases of GCA. We describe an atypical presentation of OIS and oculomotor nerve palsy with contralateral AAION in an elderly patient with a delayed diagnosis of biopsy-proven GCA. This case exemplifies the importance of suspicion, early diagnosis and initiation of treatment in GCA to prevent irreversible loss of vision.

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Publication Details

Journal
BMJ Case Reports
Published
2025-03-01
DOI
https://doi.org/10.1136/bcr-2024-262251
Primary Topic
Vasculitis and related conditions
Type
article
Field-Weighted Citation Impact
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article

Ocular ischaemic syndrome due to giant cell arteritis

Michael McLucas, A.W. Dunlop, Ethan Charles Wilkinson, Tom Ayton
BMJ Case Reports
Vasculitis and related conditions
article

Ocular ischaemic syndrome due to giant cell arteritis

Michael McLucas, A.W. Dunlop, Ethan Charles Wilkinson, Tom Ayton
article en

Abstract

Giant cell arteritis (GCA) is a large vessel vasculitis with devastating visual consequences if left untreated. Classically, GCA has a predilection for the short posterior ciliary arteries which supply the optic nerve head, causing sudden painless visual loss with the development of arteritic anterior ischaemic optic neuropathy (AAION). Other ocular manifestations of GCA include central retinal artery occlusion, oculomotor nerve palsy, posterior ischaemic optic neuropathy and ocular ischaemic syndrome (OIS). OIS is a rare clinical entity, typically stemming from severe, unilateral carotid artery disease. It may present with anterior segment ischaemia heralded by hypotony and corneal oedema. Rarely, it may occur in cases of GCA. We describe an atypical presentation of OIS and oculomotor nerve palsy with contralateral AAION in an elderly patient with a delayed diagnosis of biopsy-proven GCA. This case exemplifies the importance of suspicion, early diagnosis and initiation of treatment in GCA to prevent irreversible loss of vision.

BMJ Case ReportsVol. 18(3)
The University of Sydney (AU), John Hunter Hospital (AU), Sydney Hospital (AU), Tamworth Hospital (AU), Hunter New England Local Health District (AU)
Good health and well-being
Openalex Percentile: Top 92%
Vasculitis and related conditions
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