Transvalvular Mechanical Circulatory Support Reverse Remodels the Ischemic Chronic Failing Heart in an Ovine Model
Sixteen sheep with ischemic chronic heart failure were randomized to either 3 months of Impella 5.5 support (Abiomed) or sham. Myocardial reverse remodeling by Impella support was shown by a significant reduction of end-diastolic volume (Impella 22% reduction, and control 5% increase; P = 0.011) and end-systolic volume (Impella 20% reduction, and control 11% increase; P = 0.011). Functional measurements demonstrated improved regional ejection fraction and wall thickening in the viable myocardium of hearts supported with Impella. Supported animals had a significant decrease in wall volume, with less cardiomyocyte hypertrophy than control subjects.
Authors
- Manon Van Hecke (ORCID: https://orcid.org/0000-0002-3389-5221)
- Charlotte Van Edom (ORCID: https://orcid.org/0000-0003-2830-624X)
- Bart Meyns (ORCID: https://orcid.org/0000-0002-8110-4009)
- Steven Jacobs (ORCID: https://orcid.org/0000-0002-8083-8916)
- Randi J. Parks (ORCID: https://orcid.org/0000-0002-6829-4231)
- Magdalena Sikole
- Eveline Bennek Schoepping
- Piet Claus (ORCID: https://orcid.org/0000-0002-2013-639X)
- Erik Verbeken
Institutions
- Abiomed (Germany) (DE)
- VIB-KU Leuven Center for Microbiology (BE)
- KU Leuven (BE)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1016/j.jacbts.2025.01.003
- Citations
- 2
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78