Modulator-free stimulated Raman scattering based on a novel fiber laser

Advanced analytical methods have enhanced sample characterization, deepening our understanding of biological structures and reactions. Spectroscopic methods, including nonlinear coherent Raman spectroscopy like stimulated Raman microscopy (SRS), are valuable for imaging molecular behavior without staining. Simplifying these techniques for mass production requires low-maintenance, robust setups. Current SRS microscopy relies on acousto-optic modulators for signal recovery, which are costly and require high-power drivers, complicating integration. We present a new laser source that enables sensitive SRS signal detection without active modulation, addressing the need for a more practical and cost-effective solution.

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Publication Details

Published
2025-03-19
DOI
https://doi.org/10.1117/12.3041137
Primary Topic
Spectroscopy Techniques in Biomedical and Chemical Research
Type
article
Field-Weighted Citation Impact
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article

Modulator-free stimulated Raman scattering based on a novel fiber laser

Niklas M. Lüpken, Daniel Lutscher, Sven Dobner, Maximilian Brinkmann et al.
Spectroscopy Techniques in Biomedical and Chemical Research
article

Modulator-free stimulated Raman scattering based on a novel fiber laser

Niklas M. Lüpken, Daniel Lutscher, Sven Dobner, Maximilian Brinkmann, Tim Hellwig
article en

Abstract

Advanced analytical methods have enhanced sample characterization, deepening our understanding of biological structures and reactions. Spectroscopic methods, including nonlinear coherent Raman spectroscopy like stimulated Raman microscopy (SRS), are valuable for imaging molecular behavior without staining. Simplifying these techniques for mass production requires low-maintenance, robust setups. Current SRS microscopy relies on acousto-optic modulators for signal recovery, which are costly and require high-power drivers, complicating integration. We present a new laser source that enables sensitive SRS signal detection without active modulation, addressing the need for a more practical and cost-effective solution.

Affordable and clean energy
Openalex Percentile: Top 95%
Spectroscopy Techniques in Biomedical and Chemical Research
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