Loss of ING3 in the Prostate Leads to Activation of DNA Damage Repair Markers

Altogether, our data provide evidence that disruption of ING3 expression in prostate cells does not lead to malignant transformation and challenges the idea that ING3 acts primarily in a tumour-suppressive manner. Furthermore, this work supports the crucial role of ING3 in maintaining genomic stability, and we confirmed the embryonic lethal phenotype of homozygous <i>Ing3</i> null mice that is rescued by ectopic expression of ING3.