Immunogenic shift of arginine metabolism triggers systemic metabolic and immunological reprogramming to suppress HER2 + breast cancer
These findings suggest the possible roles of the SEP/BH<sub>4</sub>/NO axis in promoting memory T cell formation and its potential therapeutic utility for preventing HER2-positive breast cancer.
Authors
- Eun Seok Choi (ORCID: https://orcid.org/0000-0001-6073-248X)
- Veani Fernando (ORCID: https://orcid.org/0000-0002-4759-653X)
- Osama Sweef (ORCID: https://orcid.org/0000-0003-4787-113X)
- Saori Furuta (ORCID: https://orcid.org/0000-0003-1121-0487)
- Justin Szpendyk (ORCID: https://orcid.org/0000-0002-0076-4428)
- Vandana Sharma (ORCID: https://orcid.org/0000-0002-2676-3239)
- Xunzhen Zheng
- Venetia Thomas
Institutions
- University of Wyoming (US)
- Université Bourgogne Franche-Comté (FR)
- MetroHealth Medical Center (US)
- Case Comprehensive Cancer Center
- Case Western Reserve University (US)
- University of Toledo (US)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s40170-025-00384-4
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- American Cancer Society
- National Cancer Center
- Ohio Cancer Research
- University of Toledo Foundation
- National Cancer Institute