Highly expressed GCN1 is associated with cancer progression and poor prognosis in hepatocellular carcinoma patients
GCN1 overexpression was associated with HCC progression and poor prognosis, and GCN1 knockdown could suppress the proliferation, migration and invasion ability of HCC cells by regulating Wnt signaling pathway, suggesting the potential of GCN1 as a prognostic and therapeutic target for HCC.
Authors
- Zhongchao Zhang (ORCID: https://orcid.org/0000-0001-5017-5691)
- Wei Yan (ORCID: https://orcid.org/0000-0001-9569-9026)
- Zhipeng Du
- C. N. R. Rao
- Mingcun Hu
Institutions
- Union Hospital (HK)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s12935-025-03732-y
- Citations
- 1
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- National Natural Science Foundation of China