Urinary thromboxane and isoprostane levels are elevated in symptom-high T2-biomarker-low severe asthma
Raised urinary eicosanoid levels of isoprostanes and thromboxanes were associated with increased symptoms in T2-low severe asthma. Elevated excretion of these metabolites in T2-low participants could reflect increased thromboxane-receptor (TP) activation, which may be promoting increased asthma severity and bronchoconstriction. Further research and interventions are needed to explore the role of TP modulation in T2-low severe asthma.
Authors
- Johan Kolmert (ORCID: https://orcid.org/0000-0001-7116-6583)
- Timothy C. Hardman (ORCID: https://orcid.org/0000-0002-1417-9019)
- Stephen James Fowler (ORCID: https://orcid.org/0000-0002-4524-1663)
- Javier Zurita
- Adel Mansur (ORCID: https://orcid.org/0000-0002-8615-8778)
- Judy Martina Bradley (ORCID: https://orcid.org/0000-0002-7423-135X)
- Sven‐Erik Dahlén (ORCID: https://orcid.org/0000-0002-4993-4002)
- M. Chad Eastwood
- John Busby (ORCID: https://orcid.org/0000-0003-4831-7464)
- Joseph R. Arron (ORCID: https://orcid.org/0000-0001-7677-9979)
- Peter Bradding (ORCID: https://orcid.org/0000-0001-8403-0319)
- Ratko Djukanović (ORCID: https://orcid.org/0000-0001-6039-5612)
- Christopher Edward Brightling (ORCID: https://orcid.org/0000-0002-9345-4903)
- Douglas C. Cowan (ORCID: https://orcid.org/0000-0001-7297-9041)
- Douglas S. Robinson (ORCID: https://orcid.org/0000-0002-0578-740X)
- Cécile Holweg (ORCID: https://orcid.org/0000-0002-8983-6669)
- James Lordan
- Rekha Chaudhuri (ORCID: https://orcid.org/0000-0001-8007-949X)
- Ian Pavord (ORCID: https://orcid.org/0000-0002-4288-5973)
- Craig E. Wheelock (ORCID: https://orcid.org/0000-0002-8113-0653)
- D.A. Jackson (ORCID: https://orcid.org/0000-0002-7528-121X)
- P. Jane McDowell (ORCID: https://orcid.org/0000-0003-2063-7992)
- Liam Heaney
Institutions
- Queen's University Belfast (GB)
- University College Hospital (GB)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Karolinska University Hospital (SE)
- University College London Hospitals NHS Foundation Trust (GB)
- University of Leicester (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- NHS Greater Glasgow and Clyde (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Stobhill Hospital (GB)
- Karolinska Institutet (SE)
- University of Manchester (GB)
- AbbVie (United States) (US)
- University of Oxford (GB)
- NIHR Southampton Biomedical Research Centre (GB)
- University of Southampton (GB)
- University College London (GB)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1183/23120541.01089-2024
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Teva Pharmaceutical Industries
- Vårdalstiftelsen
- Regeneron Pharmaceuticals
- Celltrion
- Stiftelsen för Strategisk Forskning
- Karolinska Institutet
- Vetenskapsrådet
- Science for Life Laboratory
- Genentech
- Medical Research Council
- Center for Innovative Medicine