PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway–Deficient Acute Myeloid Leukemia
This work demonstrates that FA pathway mutations, which are frequently observed in sporadic AML, induce hypersensitivity to PLK1 inhibition, providing rationale for a novel synthetic lethal therapeutic strategy for this patient population.
Authors
- Dana K. Mitchell (ORCID: https://orcid.org/0000-0002-1022-1072)
- Elizabeth A. Sierra Potchanant (ORCID: https://orcid.org/0000-0003-0040-5916)
- Peter J.P. Croucher (ORCID: https://orcid.org/0000-0003-1437-0224)
- Aruna Wijeratne (ORCID: https://orcid.org/0000-0001-8366-2074)
- Steven D. Rhodes (ORCID: https://orcid.org/0000-0002-6551-8631)
- Aditya S. Sheth (ORCID: https://orcid.org/0000-0002-0887-8745)
- Steven P. Angus (ORCID: https://orcid.org/0000-0002-7655-657X)
- Amer Methqal Zeidan (ORCID: https://orcid.org/0000-0001-7017-8160)
- Maya Ridinger (ORCID: https://orcid.org/0000-0001-5833-5573)
- Shaomin Qian
- Ngoc Tung Tran (ORCID: https://orcid.org/0000-0003-0896-8641)
- Ka-Kui Chan
- Sheng Liu (ORCID: https://orcid.org/0000-0002-6409-9519)
- Jun Wan (ORCID: https://orcid.org/0000-0001-9286-6562)
- Christopher Davis
Institutions
- University of Indianapolis (US)
- Yale Cancer Center (US)
- Yale University (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Cardiff Metropolitan University (GB)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0260
- Citations
- 3
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 3.45
Funders
- Strong
- Riley Children's Foundation
- National Institutes of Health
- School of Medicine, Indiana University
- National Heart, Lung, and Blood Institute