Gaudichaudione H Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Disulfidptosis via Regulating NRF2‐SLC7A11 Signaling Pathway (Adv. Sci. 11/2025)

Gaudichaudione H The cover image depicts the tale of Sun Simiao, revered as the Chinese King of Medicine, who heals a tiger and a dragon through distinct methods. In article number 2411131, Pengfei Liu, Yetong Feng, Dongmei Ren, and colleagues identify Gaudichaudione H, a natural small molecule from Garcinia oligantha Merr., as an effective NRF2 activator. NRF2 functions as a transcription factor that protects cells from toxic and oxidative stress. However, Gaudichaudione H‐induced NRF2 activation enhances cell disulfidptosis, highlighting the contrasting roles of NRF2 (analogous to the herbs) in different cell death models (analogous to the tiger and dragon). [Image: see text]