3D Printed Mesh Geometry Modulates Immune Response and Interface Biology in Mouse and Sheep Model: Implications for Pelvic Floor Surgery (Adv. Sci. 11/2025)

Tissue Engineering Pelvic organ prolapse (POP) affects over 50% of women in later stages of life. This study uses melt electrowriting (MEW) 3D printing to create meshes for POP treatment, optimising design for cellular response. Meshes at 22.5° angle show improved strength, cell attachment, and tissue integration. Preclinical evaluations in animal models indicate enhanced degradation and healing, suggesting potential for improved future vaginal implants in pelvic surgery. More details can be found in article number 2405004 by Shayanti Mukherjee and co‐workers. [Image: see text]