Polymyalgia Rheumatica and Giant Cell Arteritis: A Geriatric Perspective

Glucocorticoid therapy remains effective in most cases, though adverse effects necessitate careful monitoring. Tocilizumab was required in 18% of patients due to glucocorticoid resistance or intolerance, but it caused higher relapse rates and metabolic complications. The findings emphasize the need for steroid-sparing therapies and personalized treatment approaches to improve long-term disease control. Future research should explore newer biologic treatments, optimize imaging strategies, and address resource limitations to enhance early detection and management outcomes in elderly patients.

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Publication Details

Journal
Cureus
Published
2025-03-20
DOI
https://doi.org/10.7759/cureus.80880
Citations
1
Primary Topic
Vasculitis and related conditions
Type
article
Field-Weighted Citation Impact
1.52
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article

Polymyalgia Rheumatica and Giant Cell Arteritis: A Geriatric Perspective

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article

Polymyalgia Rheumatica and Giant Cell Arteritis: A Geriatric Perspective

Zainab Bibi, Jawad Ali, Muhammad Umair Farooq, Muhammad Ayaz, Naveed Sami, Sohail Ahmad, Zia H Kakar, Muhammad Umer Roohani, Khalid Elgorashi
article en
1 citations

Abstract

Glucocorticoid therapy remains effective in most cases, though adverse effects necessitate careful monitoring. Tocilizumab was required in 18% of patients due to glucocorticoid resistance or intolerance, but it caused higher relapse rates and metabolic complications. The findings emphasize the need for steroid-sparing therapies and personalized treatment approaches to improve long-term disease control. Future research should explore newer biologic treatments, optimize imaging strategies, and address resource limitations to enhance early detection and management outcomes in elderly patients.

CureusVol. 17(3)
University of Khartoum (SD)
Openalex Percentile: Top 21%
Vasculitis and related conditions
1.52
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