Antibiotic genomic resistance prediction using deep learning models

The classification of antibiotic resistance genomes presents a substantial challenge in the field of computational biomedical data analysis. Several machine-learning techniques have been used to solve this challenge in recent years. However, training data that is not independent and identically distributed makes taught models prone to out-of-distribution generalisation difficulties, making it a major challenge. Antibiotic resistance data generally match observations from similar phylogenetic datasets, making this important. To identify antibiotic resistance in drug discovery, antimicrobial characteristics must be extracted from large datasets. This abstract discusses retrieving antibiotic-resistance genes from the 89,491-feature pseudomonas aeruginosa integrin nucleotide sequence. For data separation and processing, 1D CNNs and ANNs were used to handle this complex text. The model extracts antimicrobial resistance genomes efficiently in convolution neural networks. The 1D convolutional neural network has 98.85% efficiency, while the artificial neural network has 80.46 %. This article uses the convolutional neural network, which extracts antibiotic resistance genomic information well. These findings could help us understand antibiotic resistance and improve medication discovery. These cutting-edge machine-learning approaches provide hope in the fight against emerging microbial dangers in an era of antibiotic resistance.

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Publication Details

Journal
International Journal of Bioinformatics Research and Applications
Published
2025-01-01
DOI
https://doi.org/10.1504/ijbra.2025.145118
Primary Topic
Mycobacterium research and diagnosis
Type
article
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article

Antibiotic genomic resistance prediction using deep learning models

Shifana Rayesha, Md Afzalur Rahman, W. Aisha Banu
International Journal of Bioinformatics Research and Applications
Mycobacterium research and diagnosis
article

Antibiotic genomic resistance prediction using deep learning models

Shifana Rayesha, Md Afzalur Rahman, W. Aisha Banu
article en

Abstract

The classification of antibiotic resistance genomes presents a substantial challenge in the field of computational biomedical data analysis. Several machine-learning techniques have been used to solve this challenge in recent years. However, training data that is not independent and identically distributed makes taught models prone to out-of-distribution generalisation difficulties, making it a major challenge. Antibiotic resistance data generally match observations from similar phylogenetic datasets, making this important. To identify antibiotic resistance in drug discovery, antimicrobial characteristics must be extracted from large datasets. This abstract discusses retrieving antibiotic-resistance genes from the 89,491-feature pseudomonas aeruginosa integrin nucleotide sequence. For data separation and processing, 1D CNNs and ANNs were used to handle this complex text. The model extracts antimicrobial resistance genomes efficiently in convolution neural networks. The 1D convolutional neural network has 98.85% efficiency, while the artificial neural network has 80.46 %. This article uses the convolutional neural network, which extracts antibiotic resistance genomic information well. These findings could help us understand antibiotic resistance and improve medication discovery. These cutting-edge machine-learning approaches provide hope in the fight against emerging microbial dangers in an era of antibiotic resistance.

International Journal of Bioinformatics Research and ApplicationsVol. 21(2)
Presidency University (IN), B.S. Abdur Rahman Crescent Institute of Science & Technology (IN)
Zero hunger
Openalex Percentile: Top 92%
Mycobacterium research and diagnosis
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Antibiotic genomic resistance prediction using deep learning models — Shifana Rayesha, Md Afzalur Rahman, et al. · International Journal of Bioinformatics Research and Applications (2025) | TGRS Research Map | TGRS